KDEL Receptors Are Differentially Regulated to Maintain the ER Proteome under Calcium Deficiency
نویسندگان
چکیده
منابع مشابه
Mitochondrial and cytosolic calcium dynamics are differentially regulated in plants.
The role of mitochondrial calcium in plant cell signaling has received little attention due to the technical difficulties in measuring changes in the mitochondrial free calcium concentration ([Ca ]m) in vivo. Here, we describe the unprecedented use of targeted aequorin to produce stably transformed Arabidopsis plants that both enable the analysis of mitochondrial calcium dynamics in planta and ...
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GABA and glutamate receptors belonging to the ligand-gated chloride-channel family are primary targets of insecticides and antiparasitics, so their molecular structure, pharmacology and biophysical properties have attracted significant attention. However, little is known about the physiological roles of these channels or how they regulate neuronal excitability and animal behavior. Mechanosensor...
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The function of KDEL receptors (KDELR) is to capture endoplasmic reticulum (ER)-resident chaperones in the acidic environment of the Golgi apparatus, by recognizing their C-terminal motif, and retrieve them back to the ER [1]. Certain structural features of KDELR, for example a similar topology to that of G-protein-coupled receptors (GPCR), a large family of proteins involved in virtually all p...
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We used Hoxa3 knockout mice and other mouse models to study the role of the fetal parathyroids in fetal calcium homeostasis. Hoxa3-null fetuses lack parathyroid glands, and absence of parathyroid hormone (PTH) was confirmed with a rodent PTH immunoradiometric assay. The ionized calcium level of Hoxa3-null fetuses was significantly lower than that of wild-type or heterozygous littermates or of t...
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ژورنال
عنوان ژورنال: Cell Reports
سال: 2018
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2018.10.055